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FRS Healthy Energy
(Free Radical Scavenger)
Clinical Studies
The results of several independent scientific studies on both Quercetin and FRS
have given us a better understanding of the potential benefits of Quercetin and
FRS. We have provided these studies for your education, and to help you make
informed decisions about your performance and health. We're confident you'll find
that FRS is energy unlike any other. Click on the links below to find out more.

Dietary Antioxidant Supplementation Combined with Quercetin Improves Cycling
Time Trial Performance

Quercetin Increases Brain and Muscle Mitochondrial Biogenesis and Exercise

FRS Enhances Work Performance

FRS Has More Antioxidant Power Than Other Drinks, based on ORAC assay

FRS Fights Fatigue
FRS Inventor & Advisor Bios
Marcus Elliott, MD - Advisor - is a Harvard trained physician specializing in performance enhancement
and the care of elite athletes. He is dedicated to applying cutting edge science for optimal athletic
development. He has trained some of the world's best athletes including those at the U.S. Olympic
Training Center, the Australian Institute of Sports, and the Sports Science Institute of South Africa.
Although he has trained athletes from a wide variety of sports, since 1998 his primary focus has been
on peak performance and injury prevention in USA professional sports, including football, baseball, and
Read more about Dr. Marcus Elliot on his website

Dr. Lan Bo Chen, PhD - Advisor - is a Professor of Pathology, Emeritus, at Harvard Medical School.
He formerly worked at the Dana-Farber Cancer Institute and was active at Harvard Medical School
starting in July, 1977. Dr. Chen is the founder of several biotechnology companies, including Fuji
ImmunoPharmaceuticals Corp. and Shionogi BioResearch Corp. Dr. Chen received his B.S. in chemistry
from National Taiwan University and his PhD in cell biology from the Massachusetts Institute of
Technology. He is an expert in mitochondria, cytoskeleton, and cellular imaging techniques and has
authored over 200 academic publications. Dr Chen co-founded Synta Pharmaceuticals with Dr. Safi
Bahcall and has been a member of Synta's board of directors and the Chairman of its Scientific
Advisory Board since July 2001.

Dr. Mitsunori Ono, PhD - Inventor & Advisor is the President of MO Management, a Scientific
Consultancy with Select International Clients that include Fuji Film, Kirin Food, Jetro and Hoya. Dr. Ono
is a former President of Shionogi BioResearch and Synta Pharma and has successfully led medicinal
chemistry teams in developing multiple products through advanced clinical trials in therapeutic areas
that include HIV, cancer and autoimmune diseases. He has authored more than 65 academic
publications and over 45 USA patents. Dr Ono is one of the Scientists who worked on developing the
Patented FRS formula and until recently was a Visiting Professor at Beth Israel Deaconess Medical
Center, Harvard Medical School. Dr Ono is scheduled to join the faculty at Ritsumeikan University in
Kyoto, Japan as a Visiting Professor in January, 2009.
The Patented FRS Formula
FRS's revolutionary formula wasn't designed for athletes originally. It was developed as a general health drink by university research
doctors studying antioxidants. FRS actually stands for Free Radical Scavenger which is a scientific term for antioxidant. In their initial
studies they were surprised that people talked about increased energy, and decreased fatigue. By chance endurance athletes
discovered it and a cult following was born. In the years that have followed hundreds of pro and Olympic athletes, thousands of
competitive athletes, and over a million consumers have become passionate about FRS. Also, study after study has shown that the
antioxidants and vitamins in FRS provide sustained energy, fueling you up while supporting your health over the long haul. There's no
jittery feeling or roller-coaster ride - just prolonged energy that helps keep you focused and fully charged.

That energy comes from our secret weapon, Quercetin, a natural antioxidant found in foods like blueberries, apples and grapes. Its
incredible ability to enhance your body's energy system is what keeps you feeling energized longer. Scientists believe that Quercetin
works by mimicking the effects of exercise on the body's mitochondria (according to recent preliminary animal studies which are
currently being duplicated in humans) and by extending the body's natural adrenaline. Add a host of essential vitamins and you're
ready to tackle anything from minor workouts to major races.

So why not just eat more fruits and vegetables to get more Quercetin? It would be impossible to get the same amount of Quercetin
found in FRS by eating fruits and vegetables. You'd have to eat 80 apples to get the same amount of Quercetin in one day of FRS
(two servings). Also, FRS’s patented blend of Quercetin, vitamins, and metabolic enhancers is specifically designed to increase the
amount of Quercetin that your body can absorb. Don't worry- it’s good for you. The Quercetin in FRS has FDA GRAS status, meaning
that the FDA generally recognizes the Quercetin in FRS as safe.

Quercetin has also been studied for a wide range of other benefits including immune system support and reduced inflammation.
Read more about Quercetin at
FRS Healthy Energy
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Dietary Flavonoid Quercetin Increases VO2MAX and Endurance Capacity
J. Mark Davis, Catherine J. Carlstedt, Stephen Chen, Martin D. Carmichael, and E. Angela Murphy1
Quercetin, a natural polyphenolic flavonoid substance present in a variety of food plants, has been shown in vitro and in animal studies
to have widespread health and performance benefits resulting from a combination of biological properties, including antioxidant and
anti-inflammatory activity, as well as the ability to increase mitochondrial biogenesis. Little is known about these effects in humans,
however, especially with respect to exercise performance. The authors determined whether quercetin ingestion would enhance
maximal aerobic capacity and delay fatigue during prolonged exercise in healthy but untrained participants. Twelve volunteers were
randomly assigned to 1 of 2 treatments: (a) 500 mg of quercetin twice daily dissolved in vitamin-enriched Tang or (b) a
nondistinguishable placebo (Tang). Baseline VO2max and bike-ride times to fatigue were established. Treatments were administered for
a period of 7 days using a randomized, double-blind, placebo-controlled, crossover study design. After treatment both VO2max and
ride time to fatigue were determined. Seven days of quercetin feedings were associated with a modest increase in VO2max (3.9% vs.
placebo; p < .05) along with a substantial (13.2%) increase in ride time to fatigue (p <.05). These data suggest that as little as 7 days
of quercetin supplementation can increase endurance without exercise training in untrained participants. These benefits of quercetin
may have important implications for enhancement of athletic and military performance. This apparent increase in fitness without
exercise training may have implications beyond that of performance enhancement to health promotion and disease prevention.

1. The authors are with the Div. of Applied Physiology. Dept. of Exercise Science, Arnold School of Public Health, University of South
Carolina, Columbia, SC 29208 [AUQ1].